baby steps... swapping out the most complex part of a vehicle is a LOT of work.
there are a ton of things to consider too
People obviously consider stuff like
-will it fit?
-will I have to have a custom drive shaft made
-will the gearing work?
but what about..
-will I have to fabricate custom engine and transmission mounts?
-will the factory radiator have enough cooling power
-will I have to make custom radiator hoses?
-will I have to make custom power steering hoses?
-will cruise control still work? what has to be done to preserve it?
-will A/C still work? what has to be done to preserve it?
-will the current fuel system support diesel or will I have to upgrade the pump, filter, regulator, and lines? Will the current lines even plug into the new engine?
- lots and lots of other tiny details
being that you're going from an isuzu to an isuzu you'll probably have an easier time over all, but moving to some engine from another make and model altogether, you're in for a LOT of work.
I'm in the early stages of swapping an LS1 into my Nissan 240sx and let me tell you there are a LOT of tiny details, little crap that you don't even think about like... hmm I need to use an adapter to hook up just about EVERY hose, the wiring harness is about 6" too short so I have to cut and lengthen EVERY wire on the harness. or the fact that while the motor fits the headers do no... oops there's another grand I wasn't planning on spending.
I looked at the MUA5 transmission because it's made to work with that motor, in a similar chassis. If Isuzu had built the VX in a 5-speed they probably would have chosen that transmission as well... is it the best transmission? no, there are lots of other transmissions I'd like to use first but it's the path of least resistance, you're probably not going to find a cheaper/easier 5 speed to swap in, and it's an upgrade from the auto trans that's in there now...
Anything is possible, it's just a matter of resources.
I'm planning on looking into this swap more seriously in the spring... hopefully my LS1 project will be done by then and the bank will have some spending money.