Yes keep those manual hubs "locked" unless you have a bad CV you don't want turning, or have a tod ON/OFF switch.
Lift up the vx and give the wheels a shake to see if its a wheel bearing.
I removed my ABS fuse 'cus I hate ABS check that first
2001 Ironman Daily Driver... 3.5" suspension lift (OME912 springs and 1" spring spacer), ball joint flip, 1.5" front diff. drop, 33"x12.5 TrXus MT, 16x10 Eagle Alloy rims, Interceptor, PV muffler, K&N air filter, Alpine Supercharger, Bilstein shocks, and some trimming.
2000 Ironman Project LS-1 VX... very slow progress but someday....... ohhhhh someday......