if youre going to be making that long of a commute.. i dunno how well a vx is going to suit you, best highway mileage ive ever seen is 19 mpg.. and they do have some blind spots (you get used to them) other than that.. fantastic vehicle.. my girlfriend who HATES suvs loves driving it A. for the looks she gets and B. she says it drives like a sports car/doesnt feel like its huge (and its not)
if you use the search feature, you can find a lot of posts with people asking about problems with the VX such as windows, engines etc.. i dont think id be too worried about the mileage, the only engine troubles ive heard about on VXs/isuzus in general have happened early (like before 60k), some of the guys on this forum drive isuzus religiously, and have reported driving troopers over 200k (the vx shares an engine with them i beleive)
definately take it for a test drive to see how she suits you, thats all it took for me and i had to have it