I'll throw in my two cents on the subject...
Reliable - Yes, but get yourself an aftermarket extended warranty if you can. My $3k warrantee paid for itself already.
Daily driver - Absolutely! It's a DD for most of us here. The roughness of the ride is proportional to your local road quality. The VX is smooth on smooth roads, but it does amplify the crappiness of crappy roads.
Dealer service - Isuzu dealers generally do not stock VX parts, or for any of their models for that matter, as they are barely in the consumer market at this point. My dealer visits requiring part replacement go like this... I bring it in, they diagnose, they order parts, I take it home, parts come in 3-5 days later, I bring it back, they fix-fix. Kind of a PITA, but not a horrible inconvenience. As for the quality of service, every dealer is totally different, so your results may vary. Mine is great to me. Others hate their local dealer. It just depends.
Parts are readily available (they're just not at the dealer), and the good peeps on this board can help you track ANYTHING down in no time when the dealer can't be bothered to shake a tail feather. The supply of accessories, on the other hand (e.g., the roof rack) has started to dry up recently. You can find them on eBay, but then you're bidding for them against the rest of the VX community. Oh well...
It's a great truck to have - superbly capable and visually striking. As LBJ would say, "This dog can hunt!"
Good luck!