The biggest design issue is the window problem which everyone gets eventually. Other than that it's a pretty solid vehicle built on good Isuzu truck thinking.
As far as the engine "stories", it's the same engine and drivetrain as in the Trooper, Rodeo and Axiom. The VehiCROSS got the same engines from the same production batches, they weren't specially constructed or designed for just the VX. So you're in the same service arena as the rest of the true Isuzu-built vehicles, which has a solid track record.