James
I did a simple search on the internet for fiberglass, fiberglass enclosures, fabrication etc. and found sites that discussed their experience with fiberglass.
It is actually a very simple but time consuming process. You can buy the woven glass and resin from Walmart. All you do is cover the spare tire with something to keep the resin off of it. Most people advocate using plastic. I used wide masking tape lightly coated in WD-40 (cover the entire tire and wheel and then spray with WD-40). I think the tape is easier to mold to the shape you desire and will stay in place (its not that hard to get off either). You then cut your woven glass into small strips that are easier to handle. I cut mine into thin trapezoidal shapes so that that it was like putting the fiberglass down like you would place pieces of a pie together (but with overlapping edges). This technique works well for circular fabrication. You then place each strip separately covering/soaking it in resin as you go. It is very messy, so you better think ahead and have all of your supplies that you will need all ready set up (with extra brushes, containers, acetone, eye protection...) I did a layer of fiberglass a day allowing each layer to cure in between.
You must repeat the process several times, adding layers to get the fiberglass thick enough for the job. I opted to use MDF for the front of the enclosure as my pictures showed. I just fiberglassed the MDF to the fiberglass mold of my spare tire/wheel and covered the MDF with resin. Allow it to cure for a couple of days and finish off the details (cutting holes, placement of a speaker mount, wiring, polyfill...)
Again, it's not hard--just a pain in the rumpuss.