If you're blowing a 40 amp fuse, I'd start looking for a direct short or pinched wire. Make sure 02 sensor or other wires are not hitting hot exhaust pipes or rubbing against sharp metal.
The wiring loom problems are in the driver side headlight area. Check the loom/ wires for abrasion and bare copper.
Did you do any electrical mods, upgrades or accessories that might be tapped into these fuses?
Have you had any body work done or screwed anything into metal that may have pierced a wire or wires?
Lastly, do you have any known bad components (like a trans mode switch) that may help further diagnose the problem?
If you already replaced your mode switch , did you fill the connector(s) with protective insulating grease to keep the contacts safe from the elements?
Mode switches have been shown to cause wierd problems when they go.