Standalones have great power capability (I'd choose the newer and more advanced AEM unit over the Haltech) but they require much tuning/dyno time, and they do not have the adaptive capabilities that the stock ECU has. The AEMs are coming close, but think of it this way:
If you tune on a 80* day, with 40% humidity at sea level, the first time you drive up into the snowy mountains, your car will run like poo -because the ECU is no longer there to "learn" the weather and make appropriate changes.
The bottom line is that standalones only tune for optimum performance that ONE day, at those EXACT conditions.
I've had far better luck with ECU reflashes. They maintain the stock driveablity of the ECU, but modify the fuel/air/timing curves for more aggressive performance (if desired).
My WRX had 3 "maps" on the stock ECU. Each one was toggled by pressing the rear defrost button at WOT.
1 -street gas map, 18psi, 304 whp.
2 -race gas map, 24psi, 362 whp.
3 -valet map, no boost, <3000 rpms.
The ECU was also configured to ignore some CEL codes (like burnt EGT sensors and missing O2 sensors).
The "cracking" of the Subaru ECU was accomplished by some dedicated nerds who saw the potential $$$ possibility in it. There doesn't seem to be that kind of market here in the Isuzu community.
The question is, is Isuzu's ECU an Isuzu product? Or could we find a suitable (or exact) replacement sitting in a GM parts bin. If it's a GM ECU, then we're in business already.