I haven't had to touch mine again since using the GE Silicone and I posted up above in '04 which was a couple years after using it. so that means I haven't touched the seals in nearly 5 years...I used clear and neatly applied it and I'm hard-pressed to see anything was done compared to stock. I have no regrets whatsoever with the silicone.
I use 3M products at work and they are great... so do what your heart tells you to do.