For me, the most important issues would be the car's past history and what kind of documentation there was on the maintenance of the truck. If you are buying from the original owner, the Isuzu warranty will expire. 99 VX's had a much briefer warranty life than 2000, 01's although the truck for all practical purposes is the same. Might be a good idea to invest in an extended warranty.
Have a good mechanic whether it is you doing the work or someone else. If you are considering an Isuzu dealership to do the work, ask around to see what the reputation is of the service department.
Make sure the CD changer works, that the windows rise without slowing down or going up askew ( a common fault with the VX), no wild fluctuations of idle, strange sounds...etc. Like Kahuna said... read read read the wealth of information found here.
Lastly, if there are other VX owners close to where your potential VX buy is, ask if they will take a look at it for or with you. Owners here on the forum are pretty willing to help.
Good luck in your purchase!!!;Dr;