I'm running 285/65/18 Terra Grapplers. My shop aligned mine without complaint, and did a good job. If they had any difficulties, they didn't tell me about it (I know the owner and taught his kid; he almost certainly would have mentioned it)
I am stopping by there tomorrow - I'll ask him if they had any problems.
The only thing I noticed is that the Nittos do "track" some on crowned roads - I pull just a tad to the driver's side when I'm in the fast lane, and to the passenger's side when in the slow lane (which isn't often ). But on a nice flat road, I can practically take my hands off the wheel and go to sleep.

Ron