I see there is already some familiarity with Illinois interstates in this thread , but I'll throw in a few more options just for variety and choice.

It looks like it would add about 50 miles to the trip, but rather than catching 70 out of Ohio, you could always drop down to 64 for driving through Indiana and Illinois. In my experience anyway, 64 is always in better condition than 70. It has to do with the usual weather patterns here in IL, because in the winter, if there is snow on the ground, it usually starts on a line about as far north as Effingham (and as a byproduct, that is where the roads start getting rougher in the state).

And speaking of Effingham, I just checked the ILDOT website and it appears that 70 is currently being worked on in that area for miles on either side and another stretch farther to the west, while 64 just has a few miles of construction at the IL/IN border and a mile of so near Mount Vernon, IL.

Overall, 70 has a few less hills than 64 though, which would make for an easier drive for the VX, but 64 has better scenery along the way than 70...unless of course you LIKE pretty much non-stop cornfields/farmland. If THAT is the case, 70 is the route!

And depending on when you'd be driving through, I-64 would only put you about 45 minutes away from me at that point for meeting to grab a bite to eat. I-70 would be more like two hours.

Either way, safe and trouble-free travels.