This is the exact feedback I was hoping for so thanks to everyone who has contributed so far.
NFPGASMASK- One of the unknowns of the swap is the longevity of the stock 4L30E transmission. Because I am wanting to keep awd and TOD I am going to see how it does with a brand new 4L30E. This way if it blows in 2,000 miles I will tell everyone that the transmission wont hold the power at all. Also if you are hammering it around every turn and from stoplight to stoplight the V8 will destroy the transmission far faster than the stock V6.

DutchKiwi- I had not looked into the PCM that you had mentioned but will be doing do once I click post. The 4.6 came with the GM PCM and we will be wiring that into the stock Isuzu PCM so we can get TOD and the power reduction during shift to work with the NorthStar.

my next hurdle will be finding out of the oil pan clears and of if not finding an oil pan that will.