YES!
but the tension will go somewhere else;
like the nylon guide on the track, the one that does grab. (Wraps around the edge of the track) would be the next part to fail.
The weatherstripping would wear uneven from the glass exerting pressure on one side as it goes up and down. would be a concern.
The window tilting in the front has many documented cases of weathersrtipping wearing though by the mirror.
But I'm not trying to scare anyone away from using them.
I do maintenance for a living, it's my job to look for reasons why things don't work like they should.