The only consideration with older, higher mileage vehicles is that the synthetic will de-sludge the engine. I know Mobil-1 will do this and imagine Amsoil probably would too, so be mindful as you probably should do an earlier filter/oil change initially on such a vehicle.
Also keep in mind that Mobil-1 and Amsoil are, to the best of my knowledge, the only TRUE synthetic lubes out there. There isn't any regulation on the term "synthetic". I could actually go down to Wal-Mart and buy the cheapest oil I could find, pour it into my own containers with a drop of synthetic and sell it as "Joe's Super Synthetic" and be completely in the clear.
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