Its all about shot placement. a .22 will stop some one faster than a .45 if the .22 hits the right spot, and the .45 doesnt.

example: a security officer i know carries a .45. he had to use it about 2 months ago. the first two rounds were torso hits, one cracked a rib, the other was in and out near the coller bone. the third hit did the most damage, as it severd the femoral artery, causing the loss of the leg. he lived.

Befor you ask, it was a justified shooting.

I would tell you what or if i carry anything But Big Brother is watching this site